Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression |
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Authors: | Justin A Gosnell Tim W Christensen |
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Institution: | (1) Department of Biology, East Carolina University, Greenville, NC 27858, USA |
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Abstract: | Background Proper coordination of the functions at the DNA replication fork is vital to the normal functioning of a cell. Specifically
the precise coordination of helicase and polymerase activity is crucial for efficient passage though S phase. The Ctf4 protein
has been shown to be a central member of the replication fork and links the replicative MCM helicase and DNA polymerase α
primase. In addition, it has been implicated as a member of a complex that promotes replication fork stability, the Fork Protection
Complex (FPC), and as being important for sister chromatid cohesion. As such, understanding the role of Ctf4 within the context
of a multicellular organism will be integral to our understanding of its potential role in developmental and disease processes. |
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