Sponge non-metastatic Group I Nme gene/protein - structure and function is conserved from sponges to humans |
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Authors: | Drago Perina Maja Herak Bosnar Ru?ica Bago Andreja Miko? Matija Harcet Martina De?eljin and Helena ?etkovi? |
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Institution: | (1) Division of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, 10002 Zagreb, Croatia;(2) Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička cesta 54, 10002 Zagreb, Croatia |
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Abstract: | Background Nucleoside diphosphate kinases NDPK are evolutionarily conserved enzymes present in Bacteria, Archaea and Eukarya, with human
Nme1 the most studied representative of the family and the first identified metastasis suppressor. Sponges (Porifera) are
simple metazoans without tissues, closest to the common ancestor of all animals. They changed little during evolution and
probably provide the best insight into the metazoan ancestor's genomic features. Recent studies show that sponges have a wide
repertoire of genes many of which are involved in diseases in more complex metazoans. The original function of those genes
and the way it has evolved in the animal lineage is largely unknown. Here we report new results on the metastasis suppressor
gene/protein homolog from the marine sponge Suberites domuncula, NmeGp1Sd. The purpose of this study was to investigate the properties of the sponge Group I Nme gene and protein, and compare
it to its human homolog in order to elucidate the evolution of the structure and function of Nme. |
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