| 陷窝蛋白-1在肿瘤发生发展中的双重性 |
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| 引用本文： | 汪淑晶,张嘉宁.陷窝蛋白-1在肿瘤发生发展中的双重性[J].生命的化学,2011(2). |
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| 作者姓名： | 汪淑晶 张嘉宁 |
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| 作者单位： | 大连医科大学生物化学与分子生物学教研室; |
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| 基金项目： | 国家自然科学基金项目(30970648和31000372)资助 |
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| 摘 要： | 陷窝蛋白-1(caveolin-1)是陷窝(caveolae)的主要结构成分,在细胞内吞、胆固醇运输、信号传导、肿瘤发生中发挥重要作用。陷窝蛋白-1在肿瘤中发挥抑癌作用还是促癌作用一直存在争论:在乳腺癌、肺癌、卵巢癌中发挥抑癌基因样作用,而在前列腺癌中则发挥癌基因样作用。这一现象提示,陷窝蛋白-1在不同肿瘤中发挥作用可能不同,其生物学作用具有双重性。本文将对陷窝蛋白-1的结构、分布、表达及与肿瘤的关系作一综述。
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| 关 键 词： | 陷窝蛋白-1 肿瘤 凋亡 转移 |
The dual roles of caveolin-1 in tumorigenesis and tumor development |
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| WANG Shujing,ZHANG Jianing.The dual roles of caveolin-1 in tumorigenesis and tumor development[J].Chemistry of Life,2011(2). |
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| Authors: | WANG Shujing ZHANG Jianing |
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| Institution: | WANG Shujing,ZHANG Jianing Department of Biochemistry and Molecular Biology,Dalian Medical University,Dalian 116044,China |
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| Abstract: | Caveolin-1 is a major structural protein of caveolae and plays important roles in endocytosis,cholesterol transport,signal transduction and tumorigenesis.The exact function of caveolin-1 in tumor remains controversial.Caveolin-1 acts as a tumor suppressor in breast cancer,lung cancer and ovarian cancer,but plays an opposite role in prostate cancer.This suggests that the biological function of caveolin-1 in tumor is cell type dependent,namely it is a tumor inhibitor in some kinds of tumors,but tumor promoter... |
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| Keywords: | caveolin-1 tumor apoptosis metastasis |
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