| 5-羟色胺转运体敲除小鼠的分子和细胞改变 |
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| 引用本文： | 蒋雪.5-羟色胺转运体敲除小鼠的分子和细胞改变[J].生命的化学,2011(2). |
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| 作者姓名： | 蒋雪 |
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| 作者单位： | 重庆医科大学基础医学院; |
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| 基金项目： | 重庆市教委基金项目(渝教科[2010]5号)资助 |
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| 摘 要： | 5-羟色胺转运体(5-HTT)在神经精神心理正常功能的维持及疾病的发生和发展中起重要作用。5-HTT的表达能力减低或消失的小鼠(称为:5-HTT敲除小鼠)表现出许多行为的改变,例如:焦虑类似行为增多、对应激更加敏感和攻击性行为减少。这些行为的改变有的与携带5-HTTLPR短等位基因的人很相似。因此5-HTT敲除小鼠被作为研究5-HTTLPR多态性导致情感性精神障碍发病机制的动物模型。本文主要就5-HTT敲除小鼠的5-HT浓度和代谢、下丘脑-垂体-肾上腺皮质轴以及对其他神经递质转运体影响的分子和细胞改变进行综述。
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| 关 键 词： | 5-羟色胺转运体 5-羟色胺代谢 下丘脑-垂体-肾上腺皮质轴 应激 |
Cellular and molecular alterations in 5-HTT knockout mice |
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| JIANG Xue.Cellular and molecular alterations in 5-HTT knockout mice[J].Chemistry of Life,2011(2). |
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| Authors: | JIANG Xue |
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| Institution: | JIANG Xue Department of Biochemistry and Molecular Biology,Chongqing Medical University,Chongqing 400016,China |
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| Abstract: | The function of 5-hydroxytryptamine transporter(5-HTT) is related to the mood regulation.Mice with deficit or reduced 5-HTT function(5-HTT knockout mice) showed several behavioral changes,including increased anxiety-like behavior,more sensitive to stress and reduced aggressive behavior.Some of these behavioral alterations are similar to phenotypes found in human who have short alleles of polymorphism in 5-HT transporter linked promoter region(5-HTTLPR).Therefore,5-HTT knockout mice can be used as a tool to ... |
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| Keywords: | 5-HTT 5-HT metabolism HPA axis stress |
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