Dual role of interleukin-17 in pannus growth and osteoclastogenesis in rheumatoid arthritis |
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| Authors: | Hiroshi Ito Hidehiro Yamada Toshiko N Shibata Hirofumi Mitomi So Nomoto Shoichi Ozaki |
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| Affiliation: | (1) Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, 216-8511 Miyamae-ku, Kawasaki, Japan;(2) Department of Orthopaedic Surgery and Rheumatology, Saiseikai Yokohamashi Tobu Hospital, 3-6-1, Shimosueyoshi, 230-8765 Tsurumi-ku, Yokohama, Japan |
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| Abstract: | Introduction In a murine model, interleukin (IL)-17 plays a critical role in the pathogenesis of arthritis. There are controversies, however, regarding whether IL-17 is a proinflammatory mediator in rheumatoid arthritis (RA). We previously established an ex vivo cellular model using synovial tissue (ST)-derived inflammatory cells, which reproduced pannus-like tissue growth and osteoclastic activity in vitro. Using this model, we investigated the effects of IL-17 on pannus growth and osteoclastogenesis in RA. |
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