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Athletic humans and horses: Comparative analysis of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) expression in peripheral blood mononuclear cells in trained and untrained subjects at rest |
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| Authors: | Stefano Capomaccio Katia Cappelli Giacomo Spinsanti Marzia Mencarelli Michela Muscettola Michela Felicetti Andrea Verini Supplizi Marco Bonifazi |
| Institution: | 1.Centro di Studio del Cavallo Sportivo, Dipartimento di Patologia, Diagnostica e Clinica Veterinaria,Università degli Studi di Perugia,Perugia,Italia;2.Dipartimento di Biologia Evolutiva,Università di Siena Via Aldo Moro,Siena,Italia;3.Dipartimento di Fisiologia,Università di Siena Via Aldo Moro,Siena,Italia;4.Dipartimento di Scienze Neurologiche,Neurochirurgiche e del Comportamento Via Aldo Moro,Siena,Italia |
| Abstract: | BackgroundHorses and humans share a natural proclivity for athletic performance. In this respect, horses can be considered a reference species in studies designed to optimize physical training and disease prevention. In both species, interleukin-6 (IL-6) plays a major role in regulating the inflammatory process induced during exercise as part of an integrated metabolic regulatory network. The aim of this study was to compare IL-6 and IL-6 receptor (IL-6R) mRNA expression in peripheral blood mononuclear cells (PBMCs) in trained and untrained humans and horses. |
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