| 达托霉素生产工艺及其衍生物组合生物合成 |
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| 引用本文： | 刘伯宁,仓基勇,张华. 达托霉素生产工艺及其衍生物组合生物合成[J]. 中国生物工程杂志, 2010, 30(3): 119-124 |
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| 作者姓名： | 刘伯宁 仓基勇 张华 |
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| 作者单位： | 华北制药集团新药研发公司 国家微生物制药工程中心 石家庄 050015 |
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| 摘 要： | 作为首个进入临床应用的环脂肽类抗生素，达托霉素自2003年上市以来，适应症不断增加，市场前景良好。达托霉素的制备工艺与结构修饰，已经成为了近年抗感染用药研发的一个热点。追溯了达托霉素的发现历程，生产工艺沿革。重点介绍了达托霉素的发酵工艺，合成基因簇研究进展，以及组合生物技术在达托霉素结构修饰中的应用。
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| 关 键 词： | 达托霉素 A21978 生产工艺 发酵工艺 组合生物合成 |
| 收稿时间： | 2009-05-20 |
| 修稿时间： | 2010-08-12 |
Manufacturing Process of Daptomycin and Combinatorial Biosynthesis of Derivatives |
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| LIU Bo-ning CANG Ji-yong ZHANG Hua. Manufacturing Process of Daptomycin and Combinatorial Biosynthesis of Derivatives[J]. China Biotechnology, 2010, 30(3): 119-124 |
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| Authors: | LIU Bo-ning CANG Ji-yong ZHANG Hua |
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| Affiliation: | LIU Bo-ning CANG Ji-yong ZHANG Hua (New Drug Research , Development Center,North China Pharmaceutical Group Corporation , National Microbial Medicine Engineering , Research Center,Shijiazhuang 050015,China) |
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| Abstract: | Since the first approved lipopeptide antibiotics-datomycin launched in 2003,there were increasing indications and bright market prospects of daptomycin,resulting its manufacturing process and structure modification has become the focus of anti-infection drugs research and development.The course of leading compound A21978C and reviewed the evolution of synthetic techniques was traced.Moreover,manufacturing technology,biosynthetic gene clusters of daptomycin,and application of combinatorial biosynthesis in st... |
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| Keywords: | Daptomycin Cycle lipopeptide antibiotics Manufacturing process Fermentation technology Combinatorial biosynthesis |
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