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Long-acting contraceptive agents: esters of norethisterone with alpha- and/or beta-chain branching |
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| Authors: | T G Watson M Hosking J E Herz J V Torres J Muller A Murillo S Cruz A Shafiee M Vossoghi F Savabi |
| Affiliation: | Division of Biological/Health Sciences, Deakin University, Victoria, 3217, Australia;Department of Chemistry CIEA-IPN and the Department of Biotechnology, Institute for Biomedical Research, UNAM, Apdo. Postal 70228, Mexico 20, D.F., Mexico;Department of Chemistry, College of Pharmacy, Tehran University, Tehran, Iran;Department of Chemistry, University of Sri Lanka, Peradeniya Campus, Peradeniya, Sri Lanka |
| Abstract: | The synthesis of eighteen esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) is described. These all possess some form of alpha- and/or beta-substitution in the ester side-chain. The work was undertaken in order to evaluate any long-acting fertility control effect intrinsic in such compounds. A pentamethyl disiloxy ether was also included in the group of substances prepared for testing because of its similar substitution pattern. |
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