Bioactivity of crude extracts and some constituents of Blutaparon portulacoides (Amaranthaceae). |
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| Authors: | M J Salvador E O Ferreira E M F Pral S C Alfieri S Albuquerque I Y Ito D A Dias |
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| Affiliation: | 1. Faculdade de Ciências Farmacêuticas de Ribeirão Preto – Universidade de São Paulo, Avenida do café, Ribeirão Preto (SP), Brasil;2. Instituto de Ciências Biomédicas – Universidade de São Paulo, Avenida Prof. Lineu Prestes, São Paulo (SP), Brasil;1. Research Centre of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zhejiang University, Hangzhou, 310058, People''s Republic of China;2. Joint Centre of Zhejiang University and the Chinese University of Hong Kong on Natural Products and Toxicology Research, Zhejiang University, Hangzhou, People''s Republic of China;1. Marine Science and Technology College, Zhejiang Ocean University, Zhoushan 316022, China;2. School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China;3. National Museum of Natural History, 2300 RA Leiden, Netherlands;4. College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, China;5. School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China;1. University of Groningen, Groningen Institute for Evolutionary Life Sciences, Box 11103, 9700 CC Groningen, The Netherlands;2. Centre for Biodiversity Theory and Modelling, Station d׳Ecologie Expérimentale du CNRS, 2 route du CNRS, 09200 Moulis, France |
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| Abstract: | Crude extracts (aerial parts and roots, both dried), methylenedioxyflavonol, and a mixture of acyl steryl glycosides isolated from Blutaparon portulacoides, were assayed for their toxicity against Trypanosoma cruzi trypomastigotes and Leishmania amazonensis amastigotes from axenic cultures. The antimicrobial activity was also investigated, in a screening conducted using fifteen strains of Gram-positive and Gram-negative bacteria, along with the yeasts, Candida albicans and Candida tropicalis. To assess the antibacterial activity of the isolated compounds, the minimum inhibitory concentrations (MICs) were determined. There are no reports of acyl steryl glycosides in the genus Blutaparon and their biological activities are being evaluated for the first time. |
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