Antiproliferative activity of lichen extracts on murine myeloma cells |
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Authors: | Doriana Triggiani Donatella Ceccarelli Antonio Tiezzi Tommaso Pisani Silvana Munzi Carlo Gaggi Stefano Loppi |
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Institution: | (1) Department of Environmental Science, University of Tuscia, Largo dell’Universitŕ snc, I-01100 Viterbo, Italy;(2) Department of Environmental Science, University of Siena, Via P.A. Mattioli 4, I-53100 Siena, Italy |
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Abstract: | In the present study we report some preliminary results concerning the evaluation of antiproliferative activity on murine
myeloma cells (P3X63-Ag8.653) of crude extracts of two common lichen species, Evernia prunastri and Xanthoria parietina.
The results were evaluated by means of the MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] test, which
is commonly used to assess the activity of living cells through mitochondrial dehydrogenases. They indicated that extracts
of E. prunastri had no effect, while those of X. parietina significantly affected murine myeloma cell proliferation, with a reduction down to 75% for methanolic extracts. This opens
perspectives for deeper investigations extended also to other mammalian cell lines. |
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Keywords: | Evernia prunastri Xanthoria parietina antitumoural effect |
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