Analysis of the nucleotide sequence and electrostatic potential distribution in the Escherichia coli genome |
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| Authors: | A. A. Sorokin A. A. Osipov P. M. Beskaravainyi S. G. Kamzolova |
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| Affiliation: | (1) Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia |
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| Abstract: | Analysis of the oligonucleotide composition of the complete E. coli genome and its σ70-specific promoters shows that promoter DNA mainly contains AT-rich hexanucleotides that have functionally important physical properties (propensity to form ‘low-melting’ regions and helix bends). Comparative analysis of the electrostatic characteristics reveals that hexanucleotides corresponding to more electronegative surroundings are mostly found in promoter DNA. |
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| Keywords: | E. coli genome promoter oligonucleotide composition electrostatic potential |
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