Identification of the product oftetP gene: A possible mechanistic basis for tetracycline resistance inClostridium perfringens |
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| Authors: | N K Saksena N Truffaut |
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| Institution: | (1) Department of Medicine, State University of New York, Health Science Center, 13203 Syracuse, New York, USA;(2) Laboratoire de Génétique Microbienne, Université de Compiegne, BP-649, 60800 Compiegne, France |
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| Abstract: | Using cloning andin vitro protein synthesis we identified the polypeptide product of thetetP gene ofClostridium perfringens which is responsible for conferring resistance to tetracycline. TwoEcoRI fragments invariably share the resistance determinant in all of theClostridium perfringens isolates that we studied. Likewise, two proteins of 10 and 20 kDa were found to be conserved in all of the recombinant clones.
The 10 kDa protein appears to be responsible for the constitution of the expression oftetP gene inC. perfringens. |
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