Vacuolar proton pumps |
| |
| Authors: | Dennis K Stone Bill P Crider Thomas C Südhof Xiao-Song Xie |
| |
| Institution: | (1) Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, 75235 Dallas, Texas;(2) Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, 75235 Dallas, Texas;(3) Department of Molecular Genetics, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, 75235 Dallas, Texas |
| |
| Abstract: | Recently a new class of proton-translocating ATPases has been localized to endomembrane compartments in plant, fungal, and mammalian cells. These proton pumps are large hetero-oligomers which have an ATP hydrolytic sector that is functionally and structurally distinct from a transmembranous proton pore. Enzymatic characteristics of these proton pumps are discussed as well as the current state of knowledge regarding subunit composition and function. In addition, recent primary sequence data are discussed which indicate that these proton pumps share a common ancestor with F1F0-type proton pumps of mitochondria |
| |
| Keywords: | Proton-translocating ATPase organelle acidification evolution |
| 本文献已被 SpringerLink 等数据库收录！ |
|
