Platelet glycoprotein IIb/IIIa receptor antagonists derived from isoxazolidines |
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| Institution: | 1. Faculty of Computer Science and Engineering, Frankfurt University of Applied Sciences, Frankfurt am Main, Germany;2. Faculty of Science, Helwan University, Cairo, Egypt;3. Faculty of Computers and Information, Cairo University, Egypt;4. Scientific Research Group in Egypt (SRGE), Egypt |
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| Abstract: | A series of isoxazolidines has been synthesized as mimetics of the RGD sequence and was evaluated as antagonists of the platelet glycoprotein IIb/IIIa receptor. These compounds were shown to be highly potent GPIIb/IIIa antagonists, exhibiting submicromolar potencies. |
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