Derivatives of (R)-2-amino-5-methoxytetralin: Antagonists and inverse agonists at the dopamine D2a receptor期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Derivatives of (R)-2-amino-5-methoxytetralin: Antagonists and inverse agonists at the dopamine D2a receptor

Institution:	1. Department of Materials and Environmental Chemistry, Stockholm University, SE 106 91, Stockholm, Sweden;2. Institute of Biology, Karelian Research Center, Russian Academy of Sciences, Pushkinskaya 11, Petrozavodsk, 185910, Russian Federation

Abstract:	A series of N-arylmethyl substituted (R)-5-methoxy-2-(propylamino)tetralins has been prepared and evaluated for affinity and efficacy at dopamine (DA) D_2a receptors. The novel compounds appeared to be antagonists or inverse agonists. (R)-2-(Benzyl)propylamino]-5-methoxytetralin (7) was characterized as a potent inverse agonists at DA D_2a receptors in a ³⁵S]GTPγS binding assay.

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