Monoacetyldiglycerides as new Ca2+ mobilizing agents in rat pancreatic acinar cells |
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| Affiliation: | 1. The Institute for Advanced Study of Coastal Ecology, School of Resource and Environmental Engineering, Ludong University, Yantai, China;2. Nanjing Institute of Environmental Sciences, Ministry of Ecology and Environment of the People''s Republic of China, Nanjing, China |
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| Abstract: | Several monoacetyldiglycerides were synthesized from glycerol in search for new Ca2+ mobilizing agent in vitro. All monoacetyldiglycerides except linolenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca2+ release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivatives were chosen for further test and exhibited unique activity. |
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