DNA analysis in Turkish Duchenne/Becker muscular dystrophy families |
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| Authors: | Esra Battalo?lu Milhan Telatar Feza Deymeer Piraye Serdaro?lu Faik Kuseyri Co?kun Özdemir Memnune Apak Ashhan Tolun |
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| Institution: | (1) Biology Department, Bo aziçi University, Bebek Istanbul, Turkey;(2) Neurology Department, Istanbul University Medical School, Çapa Istanbul, Turkey;(3) Institute for Child Health, Istanbul University, Çapa Istanbul, Turkey |
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| Abstract: | Summary The molecular genetics of Duchenne/Becker muscular dystrophy was investigated in 81 affected Turkish families. Deletions were detected by multiplex polymerase chain reaction assays and cDNA Southern analyses. The distribution of the deletions along the gene and their correlation to clinical phenotype were different from the studies reported on other populations. Moreover, DNA polymorphisms in mothers were determined using 8 DNA probes and three CA repeat sequences, and a high degree of informativeness was observed. |
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