The muscle pattern of a segment of Drosophila may be determined by neurons and not by contributing myoblasts |
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| Authors: | P A Lawrence P Johnston |
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| Affiliation: | 1. Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064, India;2. Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK;3. Institute for Stem Cell Biology and Regenerative Medicine, GKVK, Bellary Road, Bangalore 560065, India;1. Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan;2. PRESTO, Japan Science and Technology Agency, Tokyo, Japan;3. Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan |
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| Abstract: | Each segment of Drosophila has a characteristic pattern of muscles. Like the segments of the cuticle and the central nervous system, the muscle pattern is ultimately dependent on the deployment of selector genes such as elements of the bithorax complex. We use nuclear transplantation to make genetic mosaics in which the donor, but not the host, is mutant for part of the bithorax complex. Making use of a muscle pattern that is found only in the male, we ask which cells have to be mutant in order to obtain mutant muscles and find that these crucial cells do not contribute to the muscles themselves. The evidence implicates neurons that innervate the muscles. Our hypothesis is that the sex and segmental identity of the motor or neurosecretory neurons determine the development of muscle pattern. |
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