Evolutionary adaptability of biological macromolecules |
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| Authors: | Michael Conrad |
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| Affiliation: | (1) Department of Computer and Communication Sciences, University of Michigan, 48109 Ann Arbor, MI, USA |
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| Abstract: | Summary The degree of gradualism with which tertiary structure and function of protein changes with stepwise changes in primary structure (assumed to be influenced by redundancy of weak bonding) is both a precondition for and consequence of evolution. The resulting selection for degree of gradualism has implications for a number of structural and functional properties of modern proteins as well as for the significance of neutral (so-called non-Darwinian) phenomena in relation to selection. |
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| Keywords: | Molecular evolution Protein structure and function Non-Darwinian evolution Molecular adaptability |
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