Proteotoxic stress and circulating cell stress proteins in the cardiovascular diseases |
| |
Authors: | Brian Henderson A. Graham Pockley |
| |
Affiliation: | (1) Department of Microbial Diseases, UCL–Eastman Dental Institute, University College London, 256 Gray’s Inn Road, London, WC1X 8LD, UK;(2) Department of Oncology The Medical School, University of Sheffield, Sheffield, UK |
| |
Abstract: | The cardiovasculature is one of the major body systems and probably the one most exposed to stress. There is clear evidence that increasing levels of cell stress proteins within the heart is cardioprotective. In addition, there is rapidly emerging evidence that secreted cell stress proteins play a role in the function of the cardiovascular tissues. Those secreted proteins have three potential functions: (1) as normal homeostatic cardiovascular signals (e.g. protein disulphide isomerase); (2) as anti-inflammatory molecules, which are able to inhibit cardiovascular pathology (e.g. Hsp27); and (iii) as pro-inflammatory signals that can induce and promote cardiovascular pathology (e.g. Hsp60). As all of these various proteins may be released—at different rates—and in different cardiovascular diseases—we need to consider the cohort of potential secreted cell stress proteins as a dynamic system (network) that can aid and/or damage the equally dynamic cardiovascular system. |
| |
Keywords: | Cardiovascular disease Molecular chaperone Protein-folding catalyst Circulating cell stress proteins Inflammation |
本文献已被 PubMed SpringerLink 等数据库收录! |
|