Myofiber stress-response in myositis: parallel investigations on patients and experimental animal models of muscle regeneration and systemic inflammation |
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| Authors: | Maurizio Vitadello Andrea Doria Elena Tarricone Anna Ghirardello Luisa Gorza |
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| Institution: | (1) Institute of Neuroscience - Padova Section, Consiglio Nazionale delle Ricerche, viale G. Colombo 3, 35121 Padova, Italy;(2) Department of Clinical and Experimental Medicine, Division of Rheumatology, University of Padova, via N. Giustiniani 2, 35128 Padova, Italy;(3) Department of Biomedical Sciences, University of Padova, viale G. Colombo 3, 35121 Padova, Italy |
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| Abstract: | Introduction The endoplasmic reticulum (ER) stress-response, evoked in mice by the overexpression of class I major histocompatibility complex
antigen (MHC-I), was proposed as a major mechanism responsible for skeletal muscle damage and dysfunction in autoimmune myositis.
The present study was undertaken to characterize in more detail the ER stress-response occurring in myofibers of patients
with inflammatory myopathies, focusing on the expression and distribution of Grp94, calreticulin and Grp75, three ER chaperones
involved in immunomodulation. |
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