Myc and Max function as a nucleoprotein complex. |
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| Authors: | E M Blackwood L Kretzner R N Eisenman |
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| Institution: | Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104. |
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| Abstract: | The Myc family of oncoproteins are thought to regulate proliferation and differentiation in a wide variety of cell types. Recent studies show that Myc proteins form sequence-specific DNA-binding complexes with Max, a new member of the helix-loop-helix leucine zipper protein class. The properties of the Myc-Max complex suggest a mechanism for Myc's function in both normal and neoplastic cell behavior. |
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