Inhibition activities of Colchicum luteum baker on lipoxygenase and other enzymes |
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Authors: | Ahmad Bashir Khan Haroon Bashir Shumaila Nisar M Hassan M |
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Affiliation: | Department of Pharmacy, University of Peshawar, NWFP, Pakistan. bashirdr2001@yahoo.com |
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Abstract: | In vitro enzymes inhibition activities of the crude methanolic extract and various fractions of Colchicum luteum Baker (Liliaceae) including chloroform, ethyl acetate, n-butanol and aqueous were carried out against actylcholinesterase, butyrylcholinesterase, lipoxygenase and urease enzymes. A significant enzyme inhibition activity (89%) is shown by the crude methanolic extract and its fractions against lipoxygenase, while low to significant activity (32-75%) was evident against butyrylcholinesterase. The crude methanolic extract and its various fractions demonstrated low activity (29-61%) against acetylcholinesterase and no activity against urease. |
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