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PON1 55 and 192 Gene Polymorphisms in Type 2 Diabetes Mellitus Patients in a Turkish Population |
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| Authors: | Mehmet Ali Ergun Erkan Yurtcu Huseyin Demirci Mustafa N. Ilhan Vahit Barkar Ilhan Yetkin Adnan Menevse |
| Affiliation: | 1. Department of Medical Genetics, Gazi University Faculty of Medicine, Besevler, 06500, Ankara, Turkey 2. Department of Medical Biology, Baskent University Faculty of Medicine, Ankara, Turkey 3. Department of Endocrinology, Balikesir Atat??rk Goverment Hospital, Balikesir, Turkey 4. Department of Public Health, Gazi University Faculty of Medicine, Besevler, Turkey 5. Department of Medical Biology and Genetics, Gazi University Faculty of Medicine, Besevler, Turkey 6. Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Besevler, Turkey |
| Abstract: | Diabetes mellitus is a multifactorial metabolic disease, caused by the complete or relative absence of insulin hormone, which results in the deterioration of carbohydrate, protein, and lipid metabolism. The PON1 55 and 192 polymorphisms have been reported to be associated with type 2 diabetes and its complications. In this study, the involvement of the PON1 55 and 192 polymorphisms and paraoxonase enzyme activity in diabetic complications was assessed. The MM and QQ genotypes were the most frequent in complications of type 2 diabetes in both of the polymorphisms. PON enzyme activity was lower in the type 2 diabetes group with respect to the control group. Regarding both genotypes and enzyme activity, correlations were found between the PON1 55 and 192 genotypes and diabetic complications. This study thus helps to outline a genotype?Cphenotype relation for the PON1 gene in a Turkish population. |
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