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Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche
Authors:Xiaoxin Hao  Hao Gu  Chiqi Chen  Dan Huang  Yuzheng Zhao  Li Xie  Yejun Zou  Hui Sophie Shu  Yaping Zhang  Xiaoxiao He  Xiaoyun Lai  Xiaocui Zhang  Bo O. Zhou  Cheng Cheng Zhang  Guo-Qiang Chen  Zhuo Yu  Yi Yang  Junke Zheng
Affiliation:1. Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China;2. Synthetic Biology and Biotechnology Laboratory, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;3. State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China;4. Department of Physiology, UT Southwestern Medical Center, Dallas, TX 75390, USA;5. Shanghai Key Laboratory of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;6. Center for Excellence in Brain Science and Intelligence Technology, Institutes of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China
Abstract:
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  • Keywords:leukemia-initiating cells  metabolic imaging  symmetric division  homing  endosteal niche  PDK2  SoNar
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