Making the right connections: biological networks in the light of evolution |
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Authors: | Christopher G Knight John W Pinney |
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Institution: | 1. Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK;2. Centre for Bioinformatics, Division of Molecular Biosciences, Imperial College London, London SW7 2AZ, UK |
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Abstract: | Our understanding of how evolution acts on biological networks remains patchy, as is our knowledge of how that action is best identified, modelled and understood. Starting with network structure and the evolution of protein–protein interaction networks, we briefly survey the ways in which network evolution is being addressed in the fields of systems biology, development and ecology. The approaches highlighted demonstrate a movement away from a focus on network topology towards a more integrated view, placing biological properties centre‐stage. We argue that there remains great potential in a closer synergy between evolutionary biology and biological network analysis, although that may require the development of novel approaches and even different analogies for biological networks themselves. |
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Keywords: | correlation network eQTL network eurovision song contest gene regulatory network protein– protein interaction network |
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