Effects of human atrial natriuretic polypeptide on pancreatic exocrine secretion in the dog |
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| Authors: | H Oguchi K Iwatsuki A Horiuchi S Furuta S Chiba |
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| Affiliation: | 1. Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan 390;1. Department of Pharmacology, Shinshu University School of Medicine, Matsumoto, Japan 390;1. MIIT Key Laboratory for Low-dimensional Quantum Structure and Devices, School of Materials Science and Engineering, Beijing Institute of Technology, 5 Zhongguancun South Street, Haidian District, Beijing, 100081, China;2. MIIT Key Laboratory for Low-dimensional Quantum Structure and Devices, School of Optics and Photonics, Beijing Institute of Technology, 5 Zhongguancun South Street, Haidian District, Beijing, 100081, China;3. Science and Technology Research Institute, China Three Gorges Corporation, 2 Liangshi Street, Tongzhou District, Beijing, 101199, China;1. Transfusion interrégionale CRS, 1066 Epalinges Vaud, Suisse;2. Université de Lausanne, faculté de biologie et de médecine, 1015 Lausanne, Suisse;3. Établissement français du sang Bretagne, 35000 Rennes, France;4. Établissement français du sang Pays-de-la-Loire, 49100 Angers, France;1. Tokat Gaziosmanpasa University, Faculty of Medicine, Department of Parasitology, Tokat, Turkey;2. Tokat Gaziosmanpasa University, Tokat Vocational School of Health Services, Department of Medical Services and Techniques, Tokat, Turkey;3. Alanya Alaaddin Keykubat University, Rafet Kayış Faculty of Engineering, Department of Genetics and Bioengineering, Antalya, Turkey;4. Tokat Gaziosmanpasa University, Artova Vocational School, Department of Veterinary Medicine, Laboratory and Veterinary Health Program, Tokat, Turkey;1. Department of Food Science, University of Parma, Parma, Italy;2. Department of Veterinary Science, University of Parma, Parma, Italy |
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| Abstract: | We examined the effects of atrial natriuretic polypeptide (hANP) on exocrine function in the isolated and blood-perfused dog pancreas in situ. Intra-arterial injection of hANP (1-10 micrograms) resulted in the dose-dependent increases of the pancreatic juice secretion. The secretory activity of 3 micrograms of hANP was approximately equal to one third of the secretory activity of 0.1 units of secretin. The use of hANP increased the concentration of bicarbonate but not that of sodium and protein in the pancreatic juice as compared with the basal values. These secretory responses to hANP were not inhibited by treatment with haloperidol, sulpiride, phentolamine, propranolol, atropine, cimetidine or ethacrynic acid. These results suggest that hANP acts directly on the pancreatic exocrine gland to stimulate pancreatic secretion; without, however, increasing sodium excretion. The mechanism of this effect remains to be elucidated. |
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