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Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling
Authors:Berezovska O  Jack C  McLean P  Aster J C  Hicks C  Xia W  Wolfe M S  Kimberly W T  Weinmaster G  Selkoe D J  Hyman B T
Institution:Alzheimer's Disease Research Laboratory, Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Charlestown, California, USA.
Abstract:
Keywords:Notch  Presenilin  Nuclear translocation  Delta
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