Theoretical model of the interactions between Ca2+, calmodulin and myosin light chain kinase |
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Authors: | Fajmut Ales Brumen Milan Schuster Stefan |
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Affiliation: | Department of Physics, Medical Faculty and Faculty of Education, University of Maribor, Slomskov trg 15, SI-2000 Maribor, Slovenia. ales.fajmut@uni-mb.si |
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Abstract: | Active Ca2+/calmodulin (CaM)-dependent myosin light chain kinase (MLCK) plays an important role in the process of MLC phosphorylation and consecutive smooth muscle contraction. Here, we propose a mathematical model of a detailed kinetic scheme describing interactions among Ca2+, CaM and MLCK and taking into account eight different aggregates. The main model result is the prediction of the Ca2+ dependent active form of MLCK, which is in the model taken as proportional to the concentration of Ca4CaM · MLCK complex. Wegscheider’s condition is additionally applied as a constraint enabling the prediction of some parameter values that have not yet been obtained by experiments. |
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Keywords: | CaM, calmodulin MLCK, myosin light chain kinase MLC, myosin light chain CaMKII, calmodulin kinase II |
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