CCN5 modulates the antiproliferative effect of heparin and regulates cell motility in vascular smooth muscle cells期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

CCN5 modulates the antiproliferative effect of heparin and regulates cell motility in vascular smooth muscle cells

Authors:	Andrew?C?Lake,John?J?Castellot Suffix" >Jr author-information" > author-information__contact u-icon-before" > mailto:john.castellot@tufts.edu" title=" john.castellot@tufts.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Program in Cell, Molecular and Developmental Biology, Sackler School of Biomedical Sciences, Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA;(2) Department of Anatomy and Cell Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA

Abstract:	Background Vascular smooth muscle cell (VSMC) hyperplasia plays an important role in both chronic and acute vascular pathologies including atherosclerosis and restenosis. Considerable work has focused on the mechanisms regulating VSMC proliferation and motility. Earlier work in our lab revealed a novel growth arrest-specific (gas) gene induced in VSMC exposed to the antiproliferative agent heparin. This gene is a member of the CCN family and has been given the name CCN5. The objective of the present study is to elucidate the function of CCN5 protein and to explore its mechanism of action in VSMC.

Keywords:
本文献已被 PubMed SpringerLink 等数据库收录！