Structure-based systems biology: a zoom lens for the cell |
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Authors: | Aloy Patrick Russell Robert B |
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Affiliation: | EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany |
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Abstract: | Systems biology seeks to explain complex biological systems, such as the cell, through the integration of many different types of information. Here, we discuss how the incorporation of high-resolution structural data can provide key molecular details often necessary to understand the complex connection between individual molecules and cell behavior. We suggest a process of zooming on the cell, from global networks through pathways to the precise atomic contacts at the interfaces of interacting proteins. |
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Keywords: | Systems biology Three-dimensional structure Protein interaction network Protein complex |
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