Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan |
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Authors: | Chih-Ching Yeh Fung-Chang Sung Reiping Tang Chung Rong Chang-Chieh Ling-Ling Hsieh |
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Institution: | (1) Department of Health Risk Management, College of Public Health, China Medical University, Taichung, 404, Taiwan, ROC;(2) Institute of Environment Health, College of Public Health, China Medical University, Taichung, 404, Taiwan, ROC;(3) Colorectal Section, Chang Gung Memorial Hospital, Linkou, Taiwan, ROC;(4) Department of Public Health, Chang Gung University, 259 Wen-Hwa 1 Road, Kwei-San, Tao-Yuan, 333, Taiwan, ROC |
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Abstract: | The relationship between diet and colorectal cancer has been previously demonstrated and supported with strong epidemiological
evidence. The role of genetic polymorphisms has, however, been less well elaborated upon. We conducted a hospital-based case–control
study including 727 cases and 736 healthy controls to evaluate the associations of the polymorphic phase-I and -II biotransformations
(CYP1A1, CYP1A2, GSTM1, GSTT1, GSTP1, NAT1 and NAT2) and DNA-repair enzymes (XRCC1, XRCC3 and XPD) with the risk of contracting colorectal cancer. We found that men featuring the CYP1A1*2C G/G genotype, the GSTT1 null genotype and XPD 751 with the Gln allele were associated with an elevated risk of colorectal cancer than were men who did not exhibit such genetic features.
Multivariate logistic regression analysis revealed that individuals featuring more than two high-risk genotypes increased
the colorectal-cancer risk 3.1-fold (OR = 3.1, 95% CI = 1.8–5.2). For women, subjects featuring the CYP1A1*2C G/G genotype and the XRCC3 Thr/Thr genotype faced a 3.1-fold greater risk (95% CI = 1.3–7.0) of colorectal cancer when compared to those featuring the CYP1A1*2C A allele and the XRCC3 Met allele. Taken together, this study suggests that polymorphisms of genes involved in biotransformation and DNA repair could
modulate colorectal-cancer risk in Taiwan. |
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Keywords: | biotransformation colorectal cancer DNA repair polymorphism |
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