Stimulation of bacterial adherence by neutrophil defensins varies among bacterial species but not among host cell types |
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Authors: | Gorter A D Hiemstra P S de Bentzmann S van Wetering S Dankert J van Alphen L |
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Affiliation: | Laboratory for Vaccine Research, National Institute for Public Health and Environment, P.O. Box 1, 3720 BA, Bilthoven, The Netherlands. annelies.gorter@rivm.nl |
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Abstract: | Adherence of Haemophilus influenzae to bronchial epithelial cells is enhanced by neutrophil defensins, which are released from activated neutrophils during inflammation [Gorter et al. (1998) J. Infect. Dis. 178, 1067-1078]. In this study, we showed that the adherence of H. influenzae to various epithelial, fibroblast-like and endothelial cell types was significantly enhanced by defensins (20 microg ml(-1)). Defensins stimulated also the adherence of Moraxella catarrhalis, Neisseria meningitidis and nonencapsulated Streptococcus pneumoniae to the NCI-H292 cell line. In contrast, defensins did not affect the adherence of Pseudomonas aeruginosa, encapsulated S. pneumoniae, Escherichia coli and Staphylococcus epidermidis. These results suggest that the defensin-enhanced adherence might support the adherence and possibly persistence of the selected bacterial species using the respiratory tract as port of entry. |
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Keywords: | Neutrophil defensin Adherence Epithelial cell Respiratory pathogen |
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