Collagenase in carcinoma cells |
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| Authors: | E D Harris C S Faulkner S Wood |
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| Institution: | 1 Department of Medicine. Dartmouth Medical School, Hanover, New Hampshire, 03755 USA;2 Department of Pathology. Dartmouth Medical School, Hanover, New Hampshire, 03755 USA;3 the Merck Institute for Therapeutic Research, Rahway, New Jersey 07065 USA |
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| Abstract: | Collagenolytic enzyme activity has been found in high levels in homogenates of a tumor (ascitic V2 carcinoma) implanted in rabbit muscle. Unlike other mammalian collagenases, this enzyme was not actively synthesized and released by primary cultures of the tumor. Most of the collagenolytic activity in tumor homogenates was found to sediment at 1000–4000 × g along with 5′-nucleotidase activity indicating that it might be bound to a membraneous component of the cell. |
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