Histones and nucleosomes in Archaea and Eukarya: a comparative analysis |
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Authors: | Suzette L Pereira J N Reeve |
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Institution: | (1) Department of Microbiology, Ohio State University, Columbus, OH 43210, USA. Tel. +1-614-292-2301; Fax +1-614-292-8120 e-mail: reeve.2@osu.edu, US |
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Abstract: | Archaeal histones from mesophilic, thermophilic, and hyperthermophilic members of the Euryarchaeota have primary sequences,
the histone fold, tertiary structures, and dimer formation in common with the eukaryal nucleosome core histones H2A, H2B,
H3, and H4. Archaeal histones form nucleoprotein complexes in vitro and in vivo, designated archaeal nucleosomes, that contain
histone tetramers and protect approximately 60 base pairs of DNA from nuclease digestion. Based on the sequence and structural
homologies and experimental data reviewed here, archaeal nucleosomes appear similar, and may be homologous in evolutionary
terms and function, to the structure at the center of the eukaryal nucleosome formed by the histone (H3+H4)2 tetramer.
Received: January 22, 1998 / Accepted: February 16, 1998 |
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Keywords: | Hyperthermophile Methanothermus fervidus Histone evolution Genome structure Nucleosome positioning |
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