Molecular dissection of a quantitative trait locus: a phenylalanine-to-tyrosine substitution in the transmembrane domain of the bovine growth hormone receptor is associated with a major effect on milk yield and composition |
| |
Authors: | Blott Sarah Kim Jong-Joo Moisio Sirja Schmidt-Küntzel Anne Cornet Anne Berzi Paulette Cambisano Nadine Ford Christine Grisart Bernard Johnson Dave Karim Latifa Simon Patricia Snell Russell Spelman Richard Wong Jerry Vilkki Johanna Georges Michel Farnir Frédéric Coppieters Wouter |
| |
Affiliation: | Department of Genetics, Faculty of Veterinary Medicine, University of Liège, 4000 Liège, Belgium. |
| |
Abstract: | We herein report on our efforts to improve the mapping resolution of a QTL with major effect on milk yield and composition that was previously mapped to bovine chromosome 20. By using a denser chromosome 20 marker map and by exploiting linkage disequilibrium using two distinct approaches, we provide strong evidence that a chromosome segment including the gene coding for the growth hormone receptor accounts for at least part of the chromosome 20 QTL effect. By sequencing individuals with known QTL genotype, we identify an F to Y substitution in the transmembrane domain of the growth hormone receptor gene that is associated with a strong effect on milk yield and composition in the general population. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |