CASA: a server for the critical assessment of protein sequence alignment accuracy |
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Authors: | Kahsay Robel Y Wang Guoli Dongre Nataraj Gao Guang Dunbrack Roland L |
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Institution: | Delaware Biotechnology Institute and Department of Electrical and Computer Engineering, University of Delaware, 15 Innovation Way, Newark, DE 19711, USA. |
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Abstract: | SUMMARY: A public server for evaluating the accuracy of protein sequence alignment methods is presented. CASA is an implementation of the alignment accuracy benchmark presented by Sauder et al. (Proteins, 40, 6-22, 2000). The benchmark currently contains 39321 pairwise protein structure alignments produced with the CE program from SCOP domain definitions. The server produces graphical and tabular comparisons of the accuracy of a user's input sequence alignments with other commonly used programs, such as BLAST, PSI-BLAST, Clustal W, and SAM-T99. AVAILABILITY: The server is located at http://capb.dbi.udel.edu/casa. |
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