Translating cancer research by synthetic biology |
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Authors: | Shankar Sumitra Pillai M Radhakrishna |
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Institution: | Integrated Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thycaud. PO, Thiruvananthapuram, 695 014, Kerala State, India. |
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Abstract: | Synthetic biology concerns applying engineering principles to biological systems. Engineering properties such as fine tuning, novel specificity, and modularity could be components of a synthetic toolkit that can be exploited to explore various issues in cancer research such as elucidation of mechanisms and pathways, creating new diagnostic tools and novel therapeutic approaches. A repertoire of synthetic biology toolkits involving DNA, RNA and protein bio-parts, have been applied to address the issues of drug target identification, drug discovery and therapeutic treatment in cancer research, thereby projecting a new dimension in oncology research. |
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