Genetic control of cross-reactive cytotoxic T-lymphocyte responses to a BALB/c tumor |
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| Authors: | John H Russell Claraine B Dobos Ralph J Graff Benjamin A Taylor |
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| Institution: | (1) Departments of Pharmacology and Genetics, Washington University School of Medicine, 660 S. Euclid Ave., 63110 St. Louis, Missouri;(2) Department of Surgery, The Jewish Hospital of St. Louis, 63110 St. Louis, Missouri;(3) The Jackson Laboratory, 04609 Bar Harbor, Maine |
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| Abstract: | Using a segregation analysis we have determined that the cross-reactive response to the DBA/2 tumor P815 by CTL from BALB/c mice immunized with a BALB/c plasmacytoma (MOPC-167) is controlled by a single gene. The gene responsible is closely linked to the dilute coat color locus on chromosome 9. In contrast, the cross-reactive response to the DBA/2 tumor L5178Y by DBA/2 anti-MOPC-167 CTL appears to be controlled by two or more genes.Abbreviations used in this paper BXD RI
C57BL/6 × DBA/2 recombinant inbred
- CD2F1
(BALB/c × DBA/2)F1
- CTL
cytotoxic thymus-derived lymphocyte
- IUdR
5 iododeoxyuridine
- PEC
peritoneal exudate cell |
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