Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin |
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| Authors: | Ogawa Akitsu Murakami Chikako Kamisuki Shinji Kuriyama Isoko Yoshida Hiromi Sugawara Fumio Mizushina Yoshiyuki |
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| Institution: | Department of Applied Biological Science, Tokyo University of Science, Noda, Chiba 278-8510, Japan. |
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| Abstract: | A new isochroman derivative named pseudodeflectusin was isolated from a culture broth of Aspergillus pseudodeflectus. The structure was determined by spectroscopic means as 9-hydroxy-7-methyl-2-(methylethylidine)-furano3,2-H]isochroman-3-one. This compound exhibited cytotoxicity for several human cancer cell lines from the stomach (NUGC-3), cervix (HeLa-S3), and peripheral blood (HL-60), but did not affect those from the lung (A549) or colon (DLD-1). The LD50 value of this compound for HL-60 cells was 39 microM. |
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