Thiourea prevents cytotoxicity and mutagenicity, but not sister-chromated exchanges in V79 cells treated with cis-diaminedichloroplatinum (II) |
| |
| Authors: | M O Bradley S Patterson L A Zwelling |
| |
| Affiliation: | 1. Merck Institute for Therapeutic Research, West Point, PA 19486, U.S.A.;2. Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, U.S.A. |
| |
| Abstract: | This work shows that cis-diaminedichloroplatinum(II)'s (cis-DDP) mutagenicity, as well as its cytotoxicity, can be prevented by subsequent treatment with thiourea. Sister-chromatid exchanges (SCE) induced by cis-DDP are only partially prevented by thiourea under conditions where mutagenicity is totally inhibited. A 4.5-h delay in the addition of thiourea following cis-DDP treatment results in an almost complete loss of its ability to prevent mutagenicity, but only a partial loss of its ability to prevent cytotoxicity and sister-chromatid exchanges. |
| |
| Keywords: | To whom correspondence should be addressed. |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
