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Uptake of GABA and Activity of GABA Transaminase in Blood Platelets from Children with Absence Epilepsy
Authors:Rainesalo  Sirpa  Eriksson  Kai  Saransaari  Pirjo  Keränen  Tapani
Institution:Brain Research Center, Medical School, University of Tampere, Tampere, Finland. sirpa.rainesalo@pshp.fi
Abstract:Childhood absence epilepsy (CAE) is a well-defined generalized epilepsy syndrome clinically characterized by frequent absence seizures. The aim of this study was to assess the activity of GABA transaminase (GABA-T) and the kinetic parameters of GABA uptake in platelets from patients with CAE. We studied 13 patients with CAE and eight sex- and age-matched controls. The mean activity of GABA-T was lower in patients with CAE than in controls (1.22+/-0.05 vs. 1.75+/-0.10 micromol/min/kg protein). The capacity of GABA uptake into the platelets was higher in patients using valproate (0.66+/-0.09 micromol/min/kg protein), but not in those using ethosuximide (0.34+/-0.05 micromol/min/kg protein), when compared to controls (0.26+/-0.06 micromol/min/kg protein). The affinity of the transporters was not altered. The observed peripheral alterations may indicate impaired function of brain GABAergic systems in children with absence epilepsy.
Keywords:Blood platelets  childhood absence epilepsy  GABA transaminase  GABA uptake  neurotransmitters
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