Novel series of O-substituted 8-quinolines and 4-benzothiazoles as potent antagonists of the bradykinin B2 receptors |
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| Authors: | Heitsch H Wagner A Schölkens B A Wirth K |
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| Affiliation: | Hoechst Marion Roussel GmbH, Frankfurt/Main, Germany. holger.heitsch@hmrag.com |
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| Abstract: | The synthesis and the SAR study of novel O-substituted 8-quinolines and 4-benzothiazoles as highly potent non-peptide bradykinin B2 receptor antagonists are described. Several members of this series of antagonists efficiently inhibited the BK-induced vasoconstriction on different isolated organ preparations. |
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