Effect of Fibrin Polymerzation on Flow Properties of Coagulating Blood |
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Authors: | P. RIHA F. LIAO J. F. STOLTZ |
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Affiliation: | (1) Institute of Hydrodynamics, Academy of Sciences, Prague, Czech Republic;(2) Department of Pharmacology, Institute of Chinese Materia Medica, Beijing, China;(3) Department of Hematology, EA 1728, Faculty of Medicine, Vandoeuvre les Nancy, France |
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Abstract: | The evolution of stress in coagulating blood is described by aMaxwell-like constitutive model. The evolution is essentiallyaffected by conversion of fibrinogen to fibrin monomer, fibrinpolymerization and its crosslinking. The modifying effects of theprocess result from the active constituents of blood plasma,blood cell concentration and intensity of flow. Interrelationof stress evolution and the kinetics of polymerization species these effects in terms of the order of the kinetics ofpolymerization and degree of fibrin polymerization and values of the constitutive coefficients. The results are presented for a normal blood, averaging the effect of blood constituents and blood platelets on coagulation. |
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Keywords: | Blood coagulation Fibrin Polymerization Blood rheology. |
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