Effect of the extent of thiolation and introduction of phosphorothioate internucleotide linkages on the anti-HIV activity of Suligovir [(s4dU)35 |
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| Authors: | Horváth András Beck Zoltán Bardos Thomas J Dunn Joseph A Aradi Janos |
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| Institution: | Department of Biochemistry and Molecular Biology, Medical and Health Science Center, Faculty of Medicine University of Debrecen, Life Science Building, Egyetem ter 1, Debrecen H-4010, Hungary. |
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| Abstract: | Suligovir is a 35-mer homo-oligonucleotide, containing exclusively 4-thio deoxyuridylate, proved to be a potent inhibitor of HIV entry. In this paper, we described the effect of extent of thiolation and the introduction of nuclease-resistant phosphorothioate linkages on the anti-HIV activity of Suligovir. We found that the decreased thiolated nucleotide content decreases the anti-HIV potency of the compound and the introduction of phosphorothioate linkages does not improve its antiviral activity. |
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