Plant Symposia and Workshops |
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| Authors: | Nadia Neyazi Taiebeh Mohammadi Farsani Zahra Nouri Mohammad Hossein Ghahremani Mohammad Reza Khorramizadeh Roksana Tajerian Elahe Motevaseli |
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| Institution: | 1.Department of Medical Biotechnology, School of Advanced Technologies in Medicine,International Campus, Tehran University of Medical Sciences,Tehran,Iran;2.Department of Oncology,Kabul Medical University,Kabul,Afghanistan;3.Department of Pharmacology and Toxicology, Faculty of Pharmacy,Tehran University of Medical Sciences,Tehran,Iran;4.Department of Molecular Medicine, School of Advanced Technologies in Medicine,Tehran University of Medical Sciences,Tehran,Iran;5.Biosensor Research Center, Endocrinilogy and Metabolism Molecular-Cellular Sciences Institute, EMRI,Tehran University of Medical Sciences,Tehran,Iran;6.Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine,Tehran University of Medical Sciences,Tehran,Iran;7.Food Microbiology Research Center,Tehran University of Medical Sciences,Tehran,Iran |
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| Abstract: | Type 2 diabetes (T2D) is a condition with insufficient insulin production or in the setting of insulin resistance with many origins including intestinal microbiota-related molecular mechanism. Insulin-degrading enzyme (IDE) is responsible for insulin breakdown in various tissues and is known as a potential drug target for T2D. Here, we assessed the effects of cell-free supernatant (CFS) and UV-killed Lactobacillus casei IBRC_M10711 on IDE expression, IDE activity, and insulin degradation in Caco-2 cell line. It was found that CFS and UV-killed L. casei IBRC_M10711 led to lower expression of IDE. UV-killed L. casei IBRC_M10711 significantly inhibited IDE activity but CFS did not. Insulin degradation was affected with none of them. In conclusion, L. casei IBRC_M10711 is effective on IDE expression and its activity, but not on insulin degradation. Future studies are recommended to explore the effect of this probiotic on other substrates of IDE. |
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