Prolyl hydroxylase activity during sea urchin development |
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| Authors: | S C Benson A Sessions |
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| Institution: | Department of Biological Sciences, California State University, Hayward, CA 94542, USA |
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| Abstract: | Prolyl hydroxylase activity appears at the blastula stage of development in the sea urchin Strongylocentrotus purpuratus and increases over 7-fold by the prism larva stage. The enzyme requires ascorbate, ferrous ions, and α-ketoglutarate for maximum activity and is inhibited by α,α′-dipyridyl. The significance of prolyl hydroxylase activity in embryonic collagen metabolism and morphogenesis is discussed. |
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