Realizing the promise of population biobanks: a new model for translation |
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Authors: | Madeleine J Murtagh Ipek Demir Jennifer R Harris Paul R Burton |
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Institution: | (1) Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester, LE1 7RH, UK;(2) Department of Sociology, University of Leicester, University Road, Leicester, LE1 7RH, UK;(3) Division of Epidemiology, The Norwegian Institute of Public Health, Oslo, Norway;(4) Department of Genetics, University of Leicester, University Road, Leicester, LE1 7RH, UK;(5) Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Purvis Hall, 1020 Pine Ave. West, Montreal, QC, H3A 1A2, Canada |
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Abstract: | The promise of science lies in expectations of its benefits to societies and is matched by expectations of the realisation of the significant
public investment in that science. In this paper, we undertake a methodological analysis of the science of biobanking and
a sociological analysis of translational research in relation to biobanking. Part of global and local endeavours to translate
raw biomedical evidence into practice, biobanks aim to provide a platform for generating new scientific knowledge to inform
development of new policies, systems and interventions to enhance the public’s health. Effectively translating scientific
knowledge into routine practice, however, involves more than good science. Although biobanks undoubtedly provide a fundamental
resource for both clinical and public health practice, their potentiating ontology—that their outputs are perpetually a promise of scientific knowledge generation—renders translation rather less straightforward than drug discovery and treatment implementation.
Biobanking science, therefore, provides a perfect counterpoint against which to test the bounds of translational research.
We argue that translational research is a contextual and cumulative process: one that is necessarily dynamic and interactive
and involves multiple actors. We propose a new multidimensional model of translational research which enables us to imagine
a new paradigm: one that takes us from bench to bedside to backyard and beyond, that is, attentive to the social and political
context of translational science, and is cognisant of all the players in that process be they researchers, health professionals, policy makers, industry representatives, members of
the public or research participants, amongst others. |
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