Reversing mother's curse revisited |
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Authors: | Hedrick Philip W |
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Institution: | School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA. philip.hedrick@asu.edu |
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Abstract: | Because of maternal mtDNA inheritance, mtDNA mutations detrimental only in males are not expected to be selected against, an effect termed the "mother's curse." However, if there is positive-assortative mating, equivalent to what was called "inbreeding" by Wade and Brandvain (2009), then selection can act to reduce the frequency of these male-specific detrimental mtDNA mutants. On the other hand, as shown here negative-assortative mating, or "outbreeding, " paradoxically can result in an increase in the frequency of male-specific detrimental mtDNA mutants. The implications of these findings are briefly discussed. |
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Keywords: | inbreeding maternal inheritance mtDNA negative‐assortative mating outbreeding positive‐assortative mating |
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