Higher-order assemblies in immune signaling:supramolecular complexes and phase separation |
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| Authors: | Shiyu Xia Zhenhang Chen Chen Shen Tian-Min Fu |
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| Affiliation: | 1.Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, MA 02115 USA ;2.Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210 USA ;3.The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210 USA |
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| Abstract: | Signaling pathways in innate and adaptive immunity play vital roles in pathogen recognition and the func-tions of immune cells.Higher-order assemblies have recently emerged as a central principle that governs immune signaling and,by extension,cellular communi-cation in general.There are mainly two types of higher-order assemblies:1) ordered,solid-like large supramolecular complexes formed by stable and rigid protein-protein interactions,and 2) liquid-like phase-separated condensates formed by weaker and more dynamic intermolecular interactions.This review covers key examples of both types of higher-order assemblies in major immune pathways.By placing emphasis on the molecular structures of the examples provided,we dis-cuss how their structural organization enables elegant mechanisms of signaling regulation. |
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| Keywords: | higher-order assembly phase separation signalosome cGAS inflammasome TCR BCR TLR RLR TNFR death domain immune signaling |
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